.MLf-'j ■ i \ t CERTIFICATS March 2, 195^ This is to certify that I have today waive * Cashier 's check No. Ml38328 of the — In the amount of $2o, 333 *33* MEMORANDUM RECEIPT FROM: SUBJECT: I hereby acknowledge receipt .of the; following: ReceiveeT" T E amount qf=& #m 3* cH ecK#!^if7zrr~^ — “ ReceivrcT~ TH£ amcl;nt df Plsas* raturn. . sijnsd eopyTissi'of’thT! Sk ATUSE OF RECIPIENT OATE RECEIVED sf ?> rmt cmsr, muss division suasscsi Invoice tie. 2/ Subproject 0, Project JKtftSHA . luvoico So* a for Subproject 3 of Project J4Kb^7RA is et- tsefce-3 : It -la rc^usatod that go gaaat- to tr4e b y two checSa la tso oaouats of $25,333*33 and $525*57 m£a out to Ifca c&ockaTfccuU 10 sost .to Chief, Ci)/|^,: through T33/3uas£V officer. v : ' ^v,. '■. ■;■ AttaeJisontoj luvoico ; CertTficaticso SlstrltutiGsr . - sib®* mtmm Chief Ohealeal Mvlalc« . 'JSi ietrTatttica: v‘ ; . .' -' ■ •''"•/’• L MOrcooee - Crlg. &•* ' CHECK^. .!:-: .: A‘ :£i::‘;T-OF S^S Cc&jptroll-ar ■»■ 1 - Exec* c>cc *y. •* 2 -1 ■••Sss/OD - a ...... . REUtiv:. . ; •■:■; FEB 1 8 m ■ : ;y- _ ■ rj#3>f . >, .;. •* ■ Vv ■/-■■■-:■ ■; " CHeck#^^. I n ths amount R eseiVGO. - • . ■. /f- 1 («CTi?xcATicia. f>rO i (JCv U vi i ivjqy w * . , , * * _ *TT — l|gi^is _ aaWa?a«aosy, that lift rate la ^1^; Gccc^Us~gd la _ t eoViaaca vltb.&ka isutual a^rooKCflt j-eaatied Sdita^^UVwlllJPiwUlMIl' C< tUia bill da jwt can'Mt aai $&*& psjMSAt tuaroQ* aso cot. y#V ^ fcieaaada* ; . ,..- • '. . • . ■ -. vv" ' * • . : -••-•■'. CateJ %i j^TcomSiT C&iOif, CD/T 53 "' m\ W Ik is certified ■ tbaV %Ma insoles es^Uoa to ^ro^-at, W -c«ay o ?P rc*cd exi that dfc* la 'coin* cabled out in oacoxdsneo with dated 3 April 1953 o&V-'tia • 5»I Tftnorantixn to -SD/A 13 Aprxt 1553 . g^aant la gut ooriaed 'nod rotated* . ' : - - • ■.• Patsi . - psfj 8 ■'" **n u . A? 4 i . ^.:H-; * v, .r-ui : » mmc^ch Pireotoir ( 3 ) j* tojfnty MrttfSALttet-tte sccpa'.of ti» ^ograa of ;aUb* jooiject 6 of Project &<Utf£A'bS3d»ea ©proved. , Ptxtoj 1 CERTiFY-THAT- FC! :rS.‘A?.C AVAJLAELEr -f <»^\i!ors£riX 5 r^rr!r^r^;^yff'^ &■%£££ TO AIUJW.C.- : f IV s. _ /- * ® i\u ■. ii'w*! wtrfiiNO Or f iC&P* memorandum receipt from: Budget Office* TSS SUBJECT: Two checks I hereby acknowledge- receipt of the following: ^ ln * ha Pro Jsft KKULTHA • plans* return. To fORM NO. 3# ., g MAR >943 . signed copy (ins) of thi * f9C * ,i ' 1 «EcTp I £»r /) CO J_ "7 DATE RECE'VtO MEMORANDUM RECEIPT 28 August 1963 DATE Budget Office, TSS subject: Two checks I hereby acknowledge receipt, of ^ -the following: Check # M1337S6 in the amount of $263.33 and check # KL33785 in the amount of §13jl66 t 67 as payment for invoice # 1, Suboroiect 8 Project MKULTRA. Pleas* return. . »lg->Aj copy(les) of this receipt 19 August 1953 K2U CKES?* FXHA338 DX7I3ICS ■ ;• ' ^ ; ..'V VIA! ■ / •' ?53/£u3gat Office* " ' i: ;.V^‘ SU3JSCT: jjffvoico Hor .1# ' SuVproJast 8* Piroiect WBUSHA.^-. ■.{ :■', Invoice I?o« l for.. Subprojsot; 0 of Project MKUi/BA la attached.^ - It lo requested that payout bo ca’io l;y tvo ct.sc/.u In. tb# GzsOvir.tQ ©» . $ 13 , 1 66.<J? oM $sS 3.33“^» cut to ehocba- ahouU v ;/ bo sent to Chief CIj/WS, T.'tl * nJ+L/z&ujm yyu«i**»- . .. Chief C*^M©ol Sivl atonj, 'T3S * Att&abroatsi : l ; : Invoice * Certifications • . , f Distribution! Mirossea - Osde* & 1 Cooutroiloi* “JLmja-- ■■ l£25» 0©Oy t> i SWiMI ' ?33/s»l??je - X-^ 233/nct*.i9-Tf - 1 * S* •*?’:*! .• X' ; •*■>*• csssTnsNBJxm-' (l) . ';It ia hereby certified that tbia la Invoice Ho. 1 apolyi r^ to twbproject 8 of Project KXULTRA,* that technical perforrsance by^ififlli gg ggggggjfc io satisfactory* that 'the vosfe is both d acccgnllstoi in oeeardanca vlth tfca mtual esres^nt reached vdtlxJgBggSgn&fSSSSt that this bill is juat art! correct and that payment thereof has cot yet been Bade* . ■: . . . * , -. y .».• • •- ■' Wf?t\ - . . .&BSEX'WSn&m- ; . ■ -•• ■,CM0f^CD/K3:' (S) "It la hereby certified that this ..invoice applies to tmbp.ojecV 8 under Project R^JLffbV which vaa dvxly approved ar4 that the project la bo ins carried out in accordance with the Bt>/? raei^rasdisa to D01 dated 3 April 1953 P3/A dated 13 April 1953 Pavcent is authorised and requested. • (3) "It is hereby certified that the ccope of the projjraa of subproject 8 ©? Project KffiJLTPA baa been epproved- ; • - Tripps ■S' Ai:. ■ :'a‘i y*-: v !■' *. ■* A *r. ■ .;v^ ce . i»ee *y •/ Jr*. 9 Jura 1953 H 2 SrvMii>II 4 FORf^ClSTOOUXii AteffXOS* Finance Division' ' SU3JS371 Project BK0K28A# StfbpVPjeot 8 "":' v • • . ’ .■<*-// A • ■■•■;■■*-'"•;-. • UaXsr tha authority granted in tbs liOKoramlua date* 13 April / 1953 f*e» the 3^2 to tba 3P/A fv^. tto further mitb-srlty s^ntod ia the m»«edua dated 17 April . 1953 ..ftfca'the BD/a to tla controller ; os tba subject, “BD/p-TOS Project l&imWY subproject 0 has been epprovoi, nal $40,290.00 of the wor^l Projeet ®S&m fund* have \^n obli4^tod to co?6r tho rebprojeot** ©xpenseat r. : . -• r -- SXOffiTf GC?PTLISD ; ■ Chief _ : Ciiesdcol Dlvioicn, £ J3 : ; em?m x?mo'm MS) KOilOTSSl- APPRCT/SD FOR CIOGATIOir ■ C? FDKDSJ ■#. • A iiorearen Cfcaissna-— ; iti;: .■ ^ Distribution* AAiroceoo - T: 3 '/ail : -et -*1 V> SSJ/.hs;;i3t¥y - 1 .- fev'ej - 2 UoMurca Hires tor Dates : tfT* JUN1'9 ENT'S Chiefs Chemical Dlvision/TSS PROGRAM VK ^BTUS FOR COlfEIKUATIOM OF REEL.WH FROJEC? ZZZ a L,S,B, - d-tltS'£aOIC'AC33) MfcXmtotlEE WSTKAfB. / Tor Include Study ofVl.S.B. Antagonists ..and Sole ted Drugs Such as L.A.ii. - lysergic Acid The prospectus for next year is in 'general a continuation of the L.S.D. project along similar lines to that of this year. Each aspect of the . project (biochemical, neurophysiological/ sociological, clinical psychiatric) to be continued. The principal addition in the broad areas of study is -that of a / psychological section which consists o f woric not ou tlined in last year* s protocol tut which nevertheless has "been going ; on during ; the year andrp 7 ‘ has brought forth substantial finding s sufficient to poin t out the necessity both of its continuation and ex pansion. 1:2" "Zy " .. Each scientific aspect of the project haa lea to the development . of procedures and ssthods which arc now of proved usefulness in the study of lysergic ami other similar drug reactions. It la the further application of the methods which liave been developed during the past year of experimentation that will be ono of the principal focuses of next year's work. These methods will be applied to the study of related chemicals such as L.A.E. and any other drugs which make their appearance, and to the study of other drugs in conjunction with L.S.D. with the goal of ascertaining antagonistic effects. V, ! o would also like to expand the base of the experiment by applying these methods to the study of patients with functional psychoses not attributable to drug reactions, Thi3 will not only test the applicability of the methods on a broader basis but will demonstrate more precisely' tha degree to "which the findings of the studies of the lysergic psychosis can bo applied to understanding schizophrenia anti other functional* psychoses. • The past year* s research has dealt to a great extent vita determining the a^ptoma produced by different dosages of L.S.B. and the degree to which tfceso cyEptons can be determined by the oocial situation in vhich the subject finds himself and by the basic personality and social attributes of the subject htoelf. For the. study of the use of other drugs in conjunction with L.S.D. to ascertain antagonistic effects it becomes necessary to develop cor© precise aeasurectents of t.S.D. effect than any which wo have had heretofore. This constitutes an essentially new field of ' investigation, na&ely :that of developing: q^^ Uvo Ecasureaents of lysergic effect. ■ . , From our to^graund of clini cal end soc ia l obs emUens of_the — _ lysergic psychosis which turn been carried on throughout the past year, sore precise and objective instruments of measurement will bo developed along the- Alloying lines: rhysiolc^icc.1 mcasurcsonts such as polygraph changes and sensitivity to spscifid p^sical ctirrali such as flashing light; _ psychological aeasummer.ts of pers is tence, m otivat ion lack , distraetibility, ri®io?y, reality perception, richness of associations; sooio^calj^ psychological mosgursaents such as quality and quantity of verbal production • in different structured social situations ouch as prcblea solving group discussion and occupational tag’s situation'; pgvcldatric detcmjnntions of rental status (which is essentially a continuation of the present method of clinical evaluation). Fart I . Elccheaical Studios These studies were carried out at the Director: L.S.F. as a stress agent upon the adrenal cortex. *el„ volunteers vers chosen. On tbs control day, merely the urines * . . , , „ «, * no o»cloCiS in the afternoon, vara collected at pre-detaredred -intervals* end 3. a„ injection of i«B, 25 ««.. *» *> th8 «»>>r i,lty ° f th “ adrenal cortex* »o urine w «o4»4 ss to>oluno, rat. per minute) end, chosically, ,s to tk. content of MU. (detemined In per 2U hours), 17 -Sctcsteroide (detemlncd fc y por ***» (determined , ky.tdU 1 ^ potL tort! _ fotassto (determined hy .dUier^ per Mur), Uric Mid (doUmMod by nilUlrsn ICT Stolsli Fhosphates (determined by nUllgra. per nimrto). on the experimental doy, tbs volunteers recolrcd i.S.D. esrly-tn tbo aornlng at . dsflnito boor.-fho nrlno a 3 sin was collected at ossotly tbs seme time intervals ea on the- control day. " ” M control exncrinenta yro carried out in vMch glucose was . given together with L*S«I3. ■ rm th. aha of the dmoK al-W endwtlons collected, no definite conclusions can bi drawn at th. present tine. See of the results .Mr. not - consistent* root. s.e»s_ to_h .ro been sooo t echnical difficulties, such as - orrors possibly rod. by the subjects thenselues with re:srd to tho d»ct time, hour end ninute, when they discorded th. first nornlns urine, and .Iso possibly son. errors In chenical dstomlnsUons. Bovorcr, froo tho overall picture of the dots which lend thrives to evaluation, tto inprosslon use gained by 75' i ■< i\Hlai uw Jauw i»l' V. . « m ^ i a AnneA as veil as by that L.SeB. oeejae to cause an inhibitory effect upon tho adrenal sorter. It is_felt that It is of utmost Snportaneo to continue those d»d«sl-*..M.ri^»«®»»' ■?«“ 5Ueht ctols53 U tho technique ere contemplated In order -to establish data which win allow a greater consistency, end therefore, better correlation. 1 ?'/j Fart IT. Antidote . Experiments A number of antidote experiments were carried cut end more arc contemplated for the futuro. Xn the course of these experiraents, the impression was gained that the molecular structure of the agent used had a definite relationship with regard to the effect of L.S.D. In some instances, the effect of L.5.D. seened to have been enhanced, a 3 for instance tho expeuriraento with ergot&ai m, while definite neutralising effects with" other agents were not yet established. / Part HI. Lysergic Acid Ethyla.mj.de . A now drugi t.A.a., became available for us and we propose to — investigate. it xore thoroughly in the coning year. This drug was developed at the Its naraa is Lysergic Acid Et hyla alde. Tide chemical ie closely related to L.S.D. the difference being asraly.that one ethyl poupf CgHg has be e n substitu ted by hydrogen” (ft) . fttoa. Prom the prelinlmry rep or t of the ve learned the foUowingT^29 experiments wore carried out on 23 normal per sons and soaa psyc hotl c s. -The -drug was given in doses ofLO.5 to 0.7 .milligrams by subcutaneous ^ inJcctf^v^WCth this amount, normal individuals expert eased a scMzophrerda-iike condition which, was characterized by adynas^, indifference, impaired volition, and phenomena of depersonalization. ■ In schizopJiroalCfl, LAE countWac ted paranoid hallucinatory excitation. That ia to say, the ecW.zophrem.ca did not loso their paranoid delusions or hallucinations , but became Indifferent to tiicaj a phenomenon which appeared to tho investigator os similar to tho effect of prefrontal lohotc.uy, and therefore, ha considered the effect of tAJv as that of a reversible ’‘checticoX lcbotosy” . 4#* ** Oa the }>asis of their observations, the investigators considered LAB as a new kind of "sedative"} a sedative which in its effect is neither related to tho group of hypnotics and narcotica of the barbituric or Borphino type, nor to the group of the syapathico- or parasyapathicolytlc chemicals* ■ ■ Tha theoretical problem presents itself to the question ea to how it la 'possible that a chemical which, in non-ol people brings about a disintegration into a schisophrenic-like condition* 13, on the other hand, 1 capable of tuning down or neutralising the excitation of a schisophrenic psychotic. Other problems present themselves, the rcost important of utiich will be tha' interaction of ME and L.S.D. It is possible to think that ME might have an antagonistic^ if net to say an antidotic; effect upon I-.S.B. ; — Part X¥. Physiological Studies i h .. 1 (Combined Eiysio-psycko-soeiological studios) The physiological changes during a lysergic psychosis rsay be colored by. use of the polygraph. fids apparatus makes it possible to study ma^ physiological parameters simultaneously. In addition a tape recording of the verbal interchange between thoTlyacrgised eubject and the examiner is synchronised with t-lto physiological record. Sociomstric classification of interactions (Sales interaction method) is carried cut also by an observer and recorded on the polygraph record. Thus the polygraph procedure can be used to obtain information at the (a) physiological, (b) psychological and (c) sociological level - all funnelod into ono record* . Analysis is being developed along the following lines* (1) difference b; tween the resting physiological values pro L«3.t?» and during lysergic psychosis, (a) Eifferenea between stress physiological values pre and during. r#7 J gii^r!iT^srm7rrii^*ntiT j --T-i^‘r-- - ». olas.ea of «. ueod W *•«*“* 1 *** iU ° “' fathering light) L <b> psychological etreaa (psychi.iric interview or, 4 specific psychological t3St). , Farther analysis relate* social classification of ycrtelitation - durinr ihe psychiatric interview with physiological factore. Thu possible to detain, vhathar pulse, tenporaturo, respiration, -OH. naecle i soci&l verbalization, activity, etc. wry an » function of -positively orivnUd . , ipMfi study is done both before negatively oriented verbalisation, or wutral. and daring lysergic psychosis •. ' •' ^ ^ , to interaction chronograph ianow being developed breur. electric engineer which toll do tha foUbtangr (l) Record on polygraph paper when ^ subject la talking and when exmincr 1° talking. ( 2 > Accvaulata thd talk tine of each party on an electric .clop* whiten .be raad^t desired intervale. (3) Give crude cstwto of decibel strength of talking of either S .1 I w 4 4 * nj *-»,e.nrrev«<ii s it h’s tosu no t ad 1 clinically subject or oMaainer. During that blocking of ecoech la an, of the earliest eigne of lyser 8 lc:Mtipn._ It hac already been shewn that verb^roductivlty 'drape during JlaJyserdia^ psychosis* “ ' Further paycto-physiolpUcal esplbraticn which we thins night hold promise would be to datetnina the nature and degree of ^aychologlcal -- etreea Wooed by (UMtaW 1" relation to the dlaorgenicing and ebnomaliclcg effect of nichorins light upon the B.B.O. : It has been observed that a 15 par second low intensity flicker wiU produce e feeling of great tension or irritnbUity In one subject wheroae it wiU bo coming and pacifying to another. This study la also to bo dene before sni during lyssrgic psychosis . A Of controlled eipcrtente were carried out to test the . „ * he iRfjuenco of US. !>.' 'in ease instances, autoaaelo nervous system un-vr v&e mu.™ • ♦ .in-n-nV'it'Md olcetyecaydiogjrophlo trscias# were Wt*n» rolWrcohi c, clectrosnccpp : »iog, •**«• ** < ■' Eg [%1 B» noo^r of coperlnent* 1» »»* mfflcl ' int W embl<1 ” „ rl va at definite coaelvolone. Son, of the oootoopUtod .^ri*oo«, for odalrdstrotlvo toasooa, havo not yot Uen corrtod o«. “ Tho eutonomle norvoaa oyot*. «»» tootod on .object. vho hod rooolved X, lS .D. orally, in the wont of one .jm*, one-half 8*4, ond gffiM per kilogroa body vol 8 ht. Too greateot^er oferparinent, «re . . carried oat on eobjecte vho had received ocrely One-soorter gam, par ^ kilojraa body volght. • lihon L.S.D. in tho onount of ono garas per kilogrpa tody ne.ght given, the injection of «U.*rl»*. M «W«* to the control, ohowed a conoid arable inhibition. Mion ono-qaartor gwra per V.llogrja tody aoight of i.S. given, a nonber of the oubjeoto aho«od a definite inhibition of aotonordo nervoca cycles on nininal aneonta of Epinophrino and iiocholyl. . m tbooo instances, Epifflphrino given in tho anoont of ,.«S oo. -of 0 «*■* 1,1000, and iiecholyl «u given in tho .scant of 2.5_«S. introsaacalarly, vtach i, ono-ouartor of tho ordinary amoont of 10 MUigraaoT-A. v. had «ntiolpa<iod ^ vith those ' ' Mscholyl* co such inhibition was noted in cases. . , At a recent conference, it «ao decided that the foWoorperlnento • , ^ia tb© amount of ©fss^nslf gawwi poi* should bs carried out with tactf, mi ,r Icilcgraa body weight* - • ; ' ®,o ospertaento seen to bo of significance lnastnch eo clinically, aotononio diotarbanoeo foll.vtns the etoinletrotion of L.S.D. ***** observed. ’ l!o Okporinentoi for adniniotraUvo reasons, hove yet teen, carried «t 1 d» ws« otineletion end adrenolytic and too loot boon given a event to atody hraan eubjecto ' ua%! tKlSSkliSteo, by methods h(t has Adapted -to lower vertebrates. Briefly* he will cet up ^ at thy 1 (now collaborating with two laboratories to study chronically mentally ill patients', response to award conditioning in term3 of their ability to . • develop desired behavior 'and to continue such behavior oyer long periods of time. As soon as fcruo hwsan laboratory is sot up and reliable curves of behavior developed in huaans to. collaboration with to teat effect of lysergic acid on the behavior curves. ; Fart V . Clinical Psychiatric Studies i'_ (1) We will continue as in the post year to sake a clinical psychiatric evaluation at the heig ht of t he reaction of ell subjects who receive L.S.D. (2) t/a will make clinical psychiatric o valuations of th© effect of drugs in combination with L.S.2. too goal in this aspect of the project: is toe evaluation of antagonistic effects. Ideally we feel it io desirable to inalco several experiments on the same subject. For example* subject with L.S.D. alone j subject with drug undo? consideration alonej subject vlth one-half doses of L.S.^» and drug j / subject with fuU dosc-a of L.S.D, and drugj and probably subject with full doaa of ons and half .dose. .of: the other. to is ideal situation io, however, limited by the desire of tho subject to have the experiment repeated on himself and past experience would indicate that very few subject a would submit to ccro than two or throe tests during, the course .of a yocr. As a result the combinations of drug and L.S.D. will be decided in eaeli instance with reference to too availability of too subject and too maxiaasi utilisation of each individual experiment. „ticuUrly Invested In ‘ho psychiatric » oc - 0 ) «« «? ^^ ' yhirfi ^ u p^.nUy «•“•«** chemical vorlwt= oi .lywgl* sc ^cal variant. with otbor - - .r -r toi3 , the *to, M » f ^ ~ «. amotion - 4 ^' ^ " (u) " ^ “V^ ^ or us.,. « - >" “ «— VH, ™ TM ^ ln lhl , ..^ Of to. -0* ,. . ** " " !a ^ 1 , t ,, reP oOUc «»' *' 3 observation h^e ce in «»* F olloicol psychiatric plot®.- piol“« a “ 5 -* *" ***'^ ^ or ««**. -*« P.-V .0 H*'. ^ " VJ^r or ioa— — 3 8 ” ‘ 1S0 Sr " ei ° n «a»»w «* ««* M * * ^ «“ wifcten nornsl Ua*t 3 sea* a of to® • **» *“•> " - ( ;,^ mTWro ii. 10 » «*»»« w , i K ,^c 83 tfco -departs® n< DfH . »«"• x» ooo«o ■» - p**^ 0 * -- T; ~ diWCU00 "' C “ ^ ^ uro. of-a oto- **i «* ‘ etoonco of optotlto *• rat3d : i " ^ ■ Increase in oppetito In ton -3 of P ^ { i r ,ain S s end of flnllnso of Intention of c llnicol ps>" ■ a 1 4 o chans. 1 " «* ^ — 13 3. 1 - .MU«- to faction in vsaieo « iyccosltrf 0 «o» . et atu 3 0 * tho Urt., W ^ 103 ° f ***** to to* *■*» * * w ^ Mnwli «e 3 —nod W ***« psychoses 0. aooontotno . - ^ ^ eccUl *•*»«* paychUtolc ovomouon - ^ lly ^ ^ 1 « toto^W® tov . to «o» o*to«t noon moved m-peo. , .,n W Wt*«*» W " aW ’ fir.s\V 9 l 3 5.3 <*? *»-» r t * This particular teat seems to to o no which ia a challenge to those people of superior intelligence and is. one which also creates fi somewhat natural stress situation* Becausa of the forsnalation -and rejection of hypotheses which is involved in the situation of this tost the subjects abil ity ta concentrate and function in a stress situation can ba ob served* His ability to shift his thinking and his ability to respond to the ©xe-niaar who can increase or decrease the stress situation by behavior and comments can also be observed* It seems as though this teat may provide a great wealth of material which should allow for correlation with behavioral observations 7 Rsdo in other than the testing situation* : ~~ 7 ~~ It will bo the ©xaalnog 1 ^ resp onsibility on thi s teat to . successfully ba an ’’amoyer® or succossfully keep the s ub ject working when he can no longer tolerate the frustration oxcsrionce in itself* Since this ia a motor task, dischsrms of tension through overactivi tv could ba observed* Perceptual 9 - u -_- nr - T ->■»-, — rT ^ — [ : — -| 7 -*«T- ~ -1 ' 1 11 * -I»ir*n- distortions could also be asked about after the tost ia completed. It would ba important to ask at too end of this tost if the subject could review his mental processes on this task which is Intangible and where it is obvious that there is a solution and an answer, whether he blames the exairdnsr for his difficulty, biases himself, shpws withdrawal or hostility in response to stress and so on could be estimated or evaluated more directly. It is suggested that the proverbs be: discontinued in tilts new e;<periEent. This is '-3 sent! ally because of tho apparent inability of the present younger generation to deal with proverbs and their apparent lade of contact with them in their everyday living. Since abstraction problems can be dealt with in the Vigotsky both in a verbal and non verbal level, it would a oca advisable that the remaining tiro® which is probably oil that tho psychologist will be given be devoted to a more specifically perceptual toot such oa the Bender-iJostult in which tho subject is required to reproduce geometric designs. Beyond thio drawing of this test it wight bo possible also to use it for richness of association in that- the subject would bo asked to tell as ®any things as each design Made them think of, or one could see how many words vas suggested to the subject by the given design in one ninute of tine. . There will be a problem especially with the Vi got sky about giving ■ the test to the person in the no mal state before he has had L,5*D« since once this test haa been solved it is r.o longer a challenge to any individual. It io suggested that for this test tho subjects all be given it first whilo 1 * 3 under L,8»D, and than have th«a take it a second tine in their noraal eta to at which tins intensive investigation be snado of t'neir feelings, attitudes, reactions, etc. Fart VXX, SociodynaaAc Studies # ' . 1. . Cosoarative Studies Using the IntsrpIayCatesoriea as Basic Tool of Hc-search During the past year th® inteplay categories have bcc-n. applied primarily at a time when distortions occur within the, limit of social situations not or sought out by tho subject. Further extension of the applica- tion of this Method are to include symptom changos of tha subject as related to interpersonal relationships and wider variety of social situations, — _ » N Soaa of the situations in which further study is indicated caroi 1, Group problen-Bolvlng situations. Lysergic subject® are I asked to work on problems of social and ethical nature, and their general conduct is to be Measured by such instruments as Bales Interaction Process Analysis and the Interaction Chronograph, in addition to the nine , interplay categories. '2, Subjects put to bed end given supportive nursing and &odieal caro. ‘ * 3, Subjects engaged In physical and eports activity. ft Described in rmarter lv reports. In conjunction with thcso studies vs wish to apply tho interplay categories in a corporative exploration of therapeutic techniques with . lysergized subjects, and normal psychoties. Judging by the party extant ^ inconclusive andoften contradictor/ reports on psychotherapeutic techniques, ; 6n intensive study of the psycholhorsboutic situation, with the aid of tba interplay categories, is 'seeded,- Little is known, for example, of how adequately or how closely therapists' self Expectation about their roles as therapists are set in an actual therapeutic interview. Moreover, with this nethod, the sequential pattern of therapeutic jittitudqs and verbal conduct.-:;: can be colored. 2* Comparative Analysis of L.S.D. end Psychotic Distortions . : ^ A further extension of the analysis of visu?l distortions in L.S.D. subjects is planned to inclu de investi ga ti on of distortions wrdch occur in psychotic patients. Farther investigations seem indicated to determine the similarity, freque coy of occurrence, and the conditions leading to and existing at the tine uhen distortions oqc'ir in psychotics ani L.S.D. subjects. Such a study is expected to lead to a such needed understanding of the cleaning of these distortions to the patient and their iKportanca in psychiatric interpretation and treatKentr ::z * ■ 3, Continuation and Kxtenaion or Methods of PersonaUlgJ^aluation the relntodnega profild (see Quarterly Report #2) focuses on the dominant bind of related/, ess, the -lovel~dr participation and the degree of stress ©xpsrieaco In the six "people proas.” ..The. clinic?! social scores tho quality of tho indixddual'a general rolateiness pattern in ten, 3 of “spontaneity vs. control" and so forth (Quarterly Report #2), A report of the use of the profile and clinical analysis will appear io tho third essentially a cohort son between the basic personality and U» **UH fceh * betora am at the heiebt or tho L.O.D. reaction. » arinTvais to tbs total available Apart froa extending tbs.s* t7po o * V s „ OT ber or cases, mreher -dies or this nature are Ured >t — clearly tho psycho-soeiai alterations or tho _M.p. cooduot « •_ • chronological honour (and prehapo' eren ninute-by-ninute) basts. » . . . «oro intensive dynamic appraisal of oreeeted that this procedure could sire a more intent «w . The f<odinre troa tho application of these nothous the ecouerce or syaptona. Iho f.ndir,, - - 7r „ , „„ (h „ith each other and Kith clinical and psychological vill bo integrated ooth wita caca findings. . . 0 n x Cooperative Study ortho rrs«tics, Syntactlce and donantlc o and Genuine Paycftosia^ - ,■_ ■ " , ana iu r — - ~— , . * resins vitiv L.S.P. ^jecte 0 uch dimculty hoc Keen * attending to lind cords vhlch cdeeuatelyc^unicato the ^ «*" : ^risnee, ot the »b 3 eot. «U is couelly tree oith the peychotica. _ror vordo T*"** “* “ f0rt '. ooonnicete W »«* to . basic. understanding of the deterioration of threat and enotional process vMch is t*bf pUco in the are transHted into a vocabulary of rhtivee vhlch ie ncardn S ful both to too subject, enperiencinz the rcellniia end to the other tryoc:-. to ur.dorst.rd .no tc9l t'„,s, the barrier to connunlcaUon continues to exist and little aid can bo riven. The tosh'set bolero us here la to understand vam in vbich «-« recline, can bo nore equate* and easily described am interpreted, to tore end ve propose to **. an intensire«eti= .** * «* ”“* W therapeutio intervleu MteriaU Thouppreach le planned to be three-rdd, 1. .^vatn or craTcatlcs , that is, a etudy or tho intentions, aoi or tho expressive behavior involved in - 1 *- # Ar ,v„is o t ^T^Tr - relationship or -a - — to each other, this oill include * •** « «* * looseness, precision and *«*•*«“• oM the »lao« * ; and flc*bility of ^oclation^accordin, * sstabUshe lews of association.) v .. . a Q study of coaUmt meaning. ■> A^aiirsts of gfeffia nUc^ that 19 * 7 f 3 . i ita "Tylosis deals »ith the waning of thins* This typo of content analysis ' ' ■ ■ oiU-ltotho sohJoot. that.ls, Vhnt ^ nest aisnifioant to the ssh 3 aet .host those thins., mother they ha prosaic, —tonal or *-#•««. eyEboUo and Interpret s » -■ : * this ty~ Of analysis, se arpact to ho' ^ided J«r o^ant-- - Uterat^ on this ssh^^U^ Behavior in ^ *W W* Jamary, 1953. M «.** fvz3.rdx* Tfogram in the accumulation of ouffieient Studios ofitho past year result in . .. h » a ajj/jn. Considerable data has infoi«ation to continue laves taction .; y k£ an .athored on tho effoot, of the i.S.i. orporionoe of <*<> porsonnol f- .. ■ of its capacity to increase -their ability to understand and «■ ^ ° f "" ; r,,is 0<^tns infomation has yot to ho aade on oid patients, Detailed analysis o. t.-.ls »«- ■ ,. vrosiiedFC pained and ho*f it ths enount and hind of understanding and sr.«l«d,o „ apollod by personnel in patient care. Sf* Two grobp experiences ero planned for further study i 1. Group sc salens will be held with personnel who hare had the experience to determine the extent of the knowledge they have gained in the Eonagecent of psychotio patients* 2. There will be group meetings in which personnel who have hsd t.S.D. end personnel who h. ve not taken the drug will • participate, the latter serving os 'jontrols. This is o-xpcctod to prove useful in a general tsdning progrna for personnel in patient management* 1, _ Salaries A. Technical B. Professional G* ■ ftyp erlasntal Subject# $ 6 , 000 . 28 , 000 , 2,500, 2 , Expendable 'Supplies A. Cheaicala, CrugB, etc. B. Records and Fhotograpa/ C. Office Supplies B. Reprints 1 , 000 . 300 . U 00 , 200 . 3» Fernanont Equip&enfc \u Travel $ 00 . 600 . T0TA.i» : ^ 50°* W -t’xt August 10 f 1954 C- to lease, €. o not try to reach co at the oM ht^ber. Ho collect calls vill be accepted at this huaiber^ Sincerely, '